Thursday, February 15, 2007

Pharm Animals Crank Out Drugs

GTC Biotherapeutics farm in Charlton, Massachusetts, looks like a typical pastoral retreat. But its 1,400 goats don't produce any butter or cheese. Instead, the animals are sophisticated drug incubators, with millions of dollars of potential profit accumulating in their udders each day. GTC Biotherapeutics is among several companies worldwide perfecting the art of "pharming" -- genetically modifying animals to churn out drugs for disorders like hemophilia and cancer.

The technique offers a way to produce large quantities of drugs that are otherwise difficult to develop. It involves genetic modification of an animal embryo's genetic makeup, or genome. Just after fertilization, "pharmers" insert into the embryo a human gene that codes for a particular protein -- usually one that's produced naturally in humans, but that's lacking in people who have certain diseases. They attach that DNA code with a gene that codes for a sugar found in mammalian milk, insuring that the therapeutic protein will be expressed only in the animals' milk or eggs.

posted by Shaun A. Saunders

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